This matchup is a race against their turn-one Phyrexian Dreadnought combo, so proactive hand disruption is key: extra Duress strips Stifle, Vision Charm, or Counterspell before they can protect the Dreadnought. Smother can't touch a 12/12 Dreadnought (mana value 1 but way over the toughness isn't the issue - it just can't kill a 12/12 since Smother only destroys, and the real problem is they'll have Stifle/countermagic backup), so swap it for Tormod's Crypt to strip their graveyard and slow Gush-fueled card draw. Phantom Nishoba is too slow and clunky against a deck trying to kill you in two attacks. Keep Pernicious Deed and Duress as the core answers to both the Dreadnought and their counterspell suite.

Naturalize is a premium answer to Opalescence, Parallax Wave, or Attunement before Replenish can bring back a full enchantment board, and should come in as a priority. The extra Duress can strip Replenish or Opalescence out of their hand before they assemble the lock. Smother and extra Ravenous Baloth are weak since this matchup is about disrupting their combo pieces, not racing creatures, so trim them. Keep Pernicious Deed as a one-card answer that wipes their entire enchantment-based board state including an animated Opalescence lock.

Terrageddon wants to Armageddon after establishing an advantage, and Naturalize is your answer to Sylvan Library or an early Mox Diamond-fueled engine piece, while also hitting Seal of Cleansing if drawn. Smother struggles since Terravore and Werebear often exceed mana value 3 quickly, so trim it down. Haunting Echoes is strong since Terravore grows from lands in all graveyards and this strips their recursive resources (Call of the Herd flashback) while also disrupting Wasteland/Rishadan Port recursion plans. Keep Wall of Roots and Wall of Blossoms as they block Wild Mongrel and Werebear well and buy time before Armageddon.