Thoughtseize is our best tool to strip a combo piece like Doomsday itself, Lion's Eye Diamond, or their Force of Will before they can assemble the kill, though the life loss is a real cost against their own aggressive Dark Ritual starts. Duress adds more proactive hand disruption to close windows for their protection spells like Daze. Once Upon a Time doesn't interact with their combo plan and Wirewood Symbiote's utility is too marginal when we need maximum disruption density. Keep our fast mana into Craterhoof Behemoth or Natural Order plan as a secondary racing angle if disruption comes up short.