Domain Zoo lives and dies by Leyline of the Guildpact enabling cheap Leyline Bindings and powering up Territorial Kavu and Scion of Draco — Force of Vigor destroys those Leylines and collapses their entire gameplan. Brotherhood's End is a clean answer to Ragavan, Nimble Pilferer and Phelia, Exuberant Shepherd that would otherwise generate too much value before your rhinos stabilize the board. Blood Moon punishes their greedy five-color mana base since they rely on fetchlands and duals with very few basics. Mystical Dispute is premium interaction for their Consign to Memory, which is their primary tool for stopping your cascade spells. Cut the slower card-advantage pieces like Wistfulness and Sink into Stupor since this matchup is decided quickly on board presence and tempo.