Living End is entirely reliant on filling its graveyard with creatures via evoke (Wistfulness, Endurance), cycling (Street Wraith), and Shardless Agent cascades to then cast the suspended Living End for a devastating swap, so proactive graveyard disruption is the top priority. Extirpate can exile every copy of a key creature they've discarded (like Shardless Agent or Generous Ent) right out of their graveyard at instant speed with split second, denying Living End's payoff before it resolves. Ashiok, Dream Render's −1 exiles their graveyard outright, wiping their entire Living End payload in one shot. Consign to Memory can counter the triggered abilities tied to their combo (such as a cascade or suspend trigger) and is a cheap way to interact on their combo turn; we trim excess lands and mill redundancy since our own mill plan is too slow to matter before they combo off.