Neobrand wants to chain Neoform and Eldritch Evolution sacrifice-creatures into Ureni, the Song Unending or Ghalta, Stampede Tyrant, so proactive interaction to stop their combo from landing is the priority. Mystical Dispute costs {2} less to cast—just one blue mana—if targeting a blue spell like Planar Genesis or Neoform, and counters target spell unless its controller pays {3}, making it flexible catch-all interaction against their combo pieces. Damping Sphere increases the cost of each spell a player casts by {1} for each other spell that player has cast that turn, hindering Neobrand's ability to chain multiple spells together on the turn they attempt to combo. We trim card-selection spells that don't interact, since this matchup is decided by whether we can counter or discard their key combo piece before it resolves — Thoughtseize is excellent here and stays in.