Brotherhood's End is a modal sweeper, so pick the mode that fits the board each time. The artifact mode destroys all artifacts with mana value 3 or less, wiping Mishra's Bauble, Mox Opal, Tormod's Crypt, Welding Jar, and Engineered Explosives, along with Pinnacle Emissary and its Drone tokens. The damage mode deals 3 damage to each creature and planeswalker, which kills their small creatures but also hits your own Ragavan, Wild Nacatl, and Territorial Kavu. A single cast can't do both. Consign to Memory is strong against Affinity's colorless artifact spells and their triggered abilities, such as Weapons Manufacturing and Urza's Saga chapter abilities, and replicate lets you stack copies at those targets. It can't counter activated abilities, and it can't counter blue spells like Kappa Cannoneer or Pinnacle Emissary, though it can still answer their triggers. Scion of Draco at mana value 12 and the clunky Quantum Riddler are too slow against Affinity's fast clock, so trim them for interaction. Keep Lightning Bolt for their small creatures and Leyline Binding as flexible removal. Kappa Cannoneer has ward {4}, so targeting it is expensive and Lightning Bolt alone won't kill it.