Devoted Combo wants to chain Devoted Druid, Delighted Halfling, and Leyline of Abundance into an explosive turn casting Green Sun's Zenith or Nature's Rhythm for a huge finisher, and the second Force of Despair blows up their whole board of enters-the-battlefield combo pieces cast in one turn. Damping Sphere taxes each additional spell they chain together, disrupting the combo's mana efficiency, and Sheoldred's Edict forces away a key Devoted Druid or Vizier of Remedies. Sorin of House Markov, March of Wretched Sorrow, Beseech the Queen, and Soul Spike are all too slow or reactive against a deck that can kill out of nowhere, so we prioritize proactive discard and disruption instead. Keep Thoughtseize and Inquisition of Kozilek maximized since stripping their combo pieces before they assemble is the best line.