Esper Ephemerate grinds with recursive value creatures like Baleful Strix and Mulldrifter, backed by Counterspell and Dispatch, so Journey to Nowhere gives you unconditional exile removal for a problematic blocker or value creature before it can be re-triggered with Ephemerate. Thraben Charm's 'destroy target enchantment' mode isn't relevant here since they have no enchantments, but its damage mode (scaling with your creature count) and graveyard-exile mode both have use against their value engine and any delve-adjacent recursion. This matchup is slower and grindier, so prioritize removal that breaks through their blockers over incremental pump; cut the lowest-impact auras to make room. Keep your hexproof shell as the primary clock since Dispatch requires metalcraft to exile and otherwise only taps your creature, and Counterspell is their main way to stop a new threat from resolving.