Affinity is almost entirely artifacts, so Dust to Dust (exiling two artifacts per cast) and Vandalblast's overload mode for {4}{R} (destroying every artifact they control) are both extremely strong, hitting Myr Enforcer, Refurbished Familiar, Utrom Monitor, Cryogen Relic, and their artifact lands alike. Melded Moxite is cut since its own artifact nature makes it a liability if they have any incidental artifact synergy, but mainly because the filtering matters less than raw hate here. Prismatic Strands is weak since Affinity's damage comes from attacking creatures rather than burn spells that share a single color, making it an inefficient answer. Deploy Vandalblast's overload as a blowout once they've committed several artifacts to the board, and use Dust to Dust on their most impactful threats or mana-fixing artifact lands.