Destroy Evil can destroy toughness-4+ threats like Bramble Wurm, Primordial Pachyderm, or Avenging Hunter (all have toughness 4+), giving you a clean answer to their biggest bodies. Cleansing Wildfire disrupts their ramp by destroying a mana-accelerating land while replenishing your hand, slowing down their Wild Growth/Utopia Sprawl-fueled starts. Arashin Cleric's life gain helps stabilize against their bigger creatures over a longer game. Relic of Progenitus and Pursue the Past aren't impactful against a straightforward ramp-into-big-creatures plan, so both are cut for more proactive answers.