Esper Ephemerate runs a heavy blue core with Counterspell, Ephemerate, and Lorien Revealed, making Pyroblast excellent for countering their key interaction or destroying a problematic Baleful Strix or Murmuring Mystic. Gorilla Shaman can destroy their artifact lands (Seat of the Synod, Ancient Den, Vault of Whispers) or Giant's Boulder, disrupting their mana base and slowing the value engine built around Ephemerate loops with Baleful Strix and Archaeomancer. Cut Gingerbrute, Wrenn's Resolve, and Chain Lightning as the weakest cards since this matchup rewards disruption of their grindy card advantage over incremental damage. Keep your core engine fully intact to close the game quickly before they out-value you with repeated enters-the-battlefield triggers.