Grixis Affinity floods the board with cheap artifacts like Ichor Wellspring and artifact lands to power out Myr Enforcer and Refurbished Familiar, so artifact removal is valuable, though note their only indestructible permanents are the Bridge artifact lands (Drossforge Bridge, Mistvault Bridge, Silverbluff Bridge), which can't be destroyed. Undergrowth Leopard can sacrifice to destroy a key nonland artifact like Ichor Wellspring or Blood Fountain to disrupt their card velocity. Vitu-Ghazi Inspector's reach helps block their ground creatures and can pick up a +1/+1 counter and life if we've filled the graveyard via collecting evidence. Mesmeric Fiend is weak here since it only grabs one card from a deck full of redundant cheap artifacts, and Quirion Ranger's tempo is too slow against this aggressive matchup.