Rakdos Sacrifice goes wide with cheap bodies like Cauldron Familiar, Eyetwitch, and Fable of the Mirror-Breaker's Goblin token, so sweeping effects are key. Withering Curse gives all creatures -2/-2, wiping their small creatures outright, and can upgrade to a full board wipe via Infusion if you've gained life that turn (e.g., from Sheoldred, the Apocalypse or Professor Dellian Fel). Invoke Despair makes them sacrifice a creature of their choice, and since they have few enchantments and no planeswalkers, the remaining steps usually make them lose 2 life and let you draw a card, which adds up to card advantage. Keep all your Sheoldred, the Apocalypse, since it is a 4/5 deathtouch body that Bloodtithe Harvester and Mayhem Devil pings do not easily remove, and it enables Infusion. Trim the two Sentinel of the Nameless City and one Unholy Annex // Ritual Chamber, which are slower and less impactful in this matchup than the sweepers.