Mono-White Humans goes wide with small aggressive humans (Dauntless Bodyguard, Thalia's Lieutenant, Kytheon) that scale with Thalia's Lieutenant counters, so Anger of the Gods and Brotherhood's End are strong sweepers that clear their early board before counters pile up (note Adeline and Arachne at higher toughness may survive, but most of the low-curve humans die). Change the Equation counters their cheap plays like Dauntless Bodyguard or Zack Fair at mana value 2 or less. The Theorist's low loyalty is exposed to their wide attacking boards, and Negate is weak since this matchup is dominated by creatures rather than key noncreature spells.