This matchup is decided before Phyrexian Dreadnought resolves — lead with Duress and Cabal Therapy to strip Stifle and Vision Charm so the Dreadnought's comes-into-play trigger resolves and forces a sacrifice. Smother is dead here since Dreadnought's converted mana cost is 12, and Phyrexian Furnace has no meaningful graveyard to disrupt, so both come out. Vendetta is your emergency answer for a resolved Dreadnought, but the 12 life loss is steep; Ravenous Baloth offsets that cost while providing a 4/4 body they have no targeted removal for — only counters and Chain of Vapor, which Baloth can preemptively sacrifice in response for 4 life. Treetop Village is a key long-game threat since it enters as a land and bypasses their counterspell suite, and Genesis generates enough card advantage to eventually overwhelm their permission.