This matchup is a race against a combo-control deck with almost no creatures, so most of our sideboard tech (Engineered Plague, Dystopia, Gloom) is dead weight since they rarely cast colored permanents those cards punish meaningfully. The extra Diabolic Edict is marginal insurance against any animated Opalescence threat but mainly we rely on our existing hand disruption. Duress and Cabal Therapy are premium here, stripping Replenish or Decree of Silence before they can assemble the lock; keep pressure on with Mishra's Factory and Nantuko Shade since they have very few ways to interact with creatures.