Omniscience Combo wins by assembling Omniscience with Uthros, Titanic Godcore and Roiling Dragonstorm through card selection from Stock Up and Consult the Star Charts. Aven Interrupter is your best disruption — countering Omniscience or a key tutor puts them substantially behind. Kutzil's Flanker disrupts their ability to cast spells during key windows. Cathar Commando can destroy Grand Abolisher which would otherwise lock you out of interaction. Avatar's Wrath and Bovine Intervention don't address the combo; Rest in Peace is irrelevant since they don't use the graveyard.