Omniscience Combo assembles via Stock Up and Consult the Star Charts into Omniscience, then deploys Uthros, Titanic Godcore and fires Roiling Dragonstorm for lethal. Deep-Cavern Bat is your premier disruption — strip Omniscience or a key tutor from their hand before it's deployed. Annul counters Grand Abolisher or key enchantments that would otherwise lock you out. Requiting Hex provides pressure that demands their attention. Day of Black Sun and Glarb, Calamity's Augur have no relevant board to interact with, and Harvester of Misery doesn't impact a spell-based combo.