Meltdown at X=0 or X=1 can destroy their Lotus Petal, Giant's Boulder, and Expedition Map before Trinisphere taxes matter, while Ratchet Bomb can eventually clear their artifact-heavy board including Trinisphere itself. Strix Serenade counters their Karn, the Great Creator or The One Ring before it resolves, leaving them a token but denying the powerful permanent. Mishra's Bauble is weak since this opponent has no pressure to punish slow draws and their own deck is full of card selection, so trim some. The key is disrupting their lock pieces (Trinisphere, Karn) before they can lock out your mana development.