Mystic Forge Combo relies on Karn, the Great Creator to fetch Mycosynth Lattice-style pieces and cast spells off the top via Mystic Forge, so Pithing Needle can shut down Karn's static ability source or a key artifact's activated ability. Abrade destroys target artifact outright, giving us a clean answer to Mystic Forge or The One Ring, while Disruptor Flute naming Karn, the Great Creator taxes their most important piece by {3} and locks its activated abilities. We trim slower cantrip pieces since this matchup rewards proactive disruption of their engine over raw card draw.