Neobrand aims to combo off quickly using green cards like Summoner's Pact, Eldritch Evolution, and Neoform, and while its finishers are largely green/colorless, its own sideboard shows it fears blue interaction, so Mystical Dispute is still useful as a cheap catch-all counterspell against any of their blue-costed spells like Consign to Memory or Planar Genesis, and functions as a Mana Leak-equivalent against everything else for {2}{U}. Nihil Spellbomb disrupts their Emperor of Bones-adjacent or graveyard-based recursion lines and denies delve fuel for Hooting Mandrills. Cut the slow Faithful Mending and situational Spell Pierce since this matchup is a race where you need your Thoughtseize and Force of Negation doing proactive disruption against their combo pieces, not card filtering. Keep Thoughtseize as a top priority to strip their key combo enablers like Summoner's Pact or Neoform before they can chain their engine.