Force of Vigor is cascade-safe and can destroy Agatha's Soul Cauldron or Leyline of Abundance, cutting off key pieces of their mana and counter-synergy engine. Teferi, Time Raveler forces them to play at sorcery speed, and its −3 can bounce Vizier of Remedies to delay their combo while drawing a card. Force of Negation is cut in full since their primary combo pieces (Devoted Druid and Vizier of Remedies) are creature spells it cannot counter, and we would rather develop our own board. Keep the full core engine and prioritize racing them to a Living End resolution before they assemble Devoted Druid plus Vizier of Remedies.