Affinity's board is almost entirely artifacts (Myr Enforcer, Refurbished Familiar, Utrom Monitor, Baleful Strix, Cryogen Relic, Giant's Boulder), so Dust to Dust exiling two at a time is extremely efficient, hitting their affinity cost-reducers and their threats simultaneously. Journey to Nowhere answers their one non-artifact threat, Glint Hawk, as well as anything else that slips through, with unconditional exile. Their maindeck has no red, so anti-red cards like Hydroblast have no relevance from their side, and they have no way to interact with your removal once it resolves since Dispatch only taps or exiles via metalcraft and doesn't counter spells. Prioritize stripping their artifact count low enough that Myr Enforcer and Thoughtcast become uncastable while racing with your own aggressive curve.